Obverse: The obverse depicts a portrait of Rita Levi-Montalcini, Nobel Prize winner in medicine. At the top in the shape of an arch is the inscription "RITA LEVI-MONTALCINI"; on the left is "RI", the abbreviation of the Italian Republic; "R" for the Mint of Rome; below is the year of manufacture "2024"; on the right is "SP", the initials of designer Silvia Petrassi and the twelve stars of the European Union.
Reverse: The reverse of the coin depicts the denomination and a map of Europe.